Your Weekly Dose 6.27: All the Vaccine News You Missed

California passes a landmark vaccine mandate, the CDC issues a cautious meningitis recommendation, and pre-cancerous lesions show a steep decline thanks in part to the HPV vaccine. Plus: A father’s moving testimony supports California’s stricter vaccine regulations.

SB277 Passes: The California assembly approved a bill that would end students’ vaccine exemptions for personal or religious beliefs—making it one of the nation’s strictest vaccine regulations. [LA Times]

A Father’s Moving Testimony: Among the many who spoke out in support of SB277? Carl Krewitt, father of a 7-year-old leukemia survivor who could not be vaccinated. “I know what fear is because I was in the hospital with a kid whose odds of survival were pretty low. But what scared me more than the threat of disease was the misinformation” about vaccines. [Santa Cruz Sentinel]

CDC Panel Cautious on New Meningitis Vaccine Recommendation: A panel of health experts recommended a limited use of the relatively new meningitis (type b) vaccine. While the recommendation is a step forward, it fell short of a stronger recommendation for routine administration wanted by many of the parents and patients who testified in front of the panel. [NY Times]

Pre-Cancerous Cervical Lesions Decline: Although we won’t have direct proof for years that HPV vaccination can prevent cervical cancers, we’re seeing a drop in the number of young women with pre-cancerous cervical lesions — and that’s a great sign! [Health Day]

5 Trustworthy Vaccine Facebook Accounts to Like Now

Last week we told you about 5 great Twitter accounts to follow for reliable and useful immunization information. Another great place to connect with the immunization community? Facebook. We love these five immunization-related accounts for their important insights, timely news items, and (most importantly) accurate information. Like them now!

Voices For Vaccines: Voices for Vaccines is a group of parents dedicated to providing clear, science-based information on vaccines to help all parents make informed decisions for their children. The Facebook page provides useful, effective strategies for interacting with people who might have questions or concerns about vaccines on social media, plus insight into timely legislation like SB277, the California bill that would require all students to be vaccinated.

Nurses Who Vaccinate: Nurses Who Vaccinate’s goal is to enable healthcare professionals to be reliable, informed vaccine advocates. But the page is a great resource even if you don’t work in healthcare. Check here for updates on global news, such as the MERS outbreak in South Korea, practical information on keeping your vaccine status up to date, and stories showing the life-saving impact of immunizations around the world.

Immunize Colorado: This page is run by Colorado Department of Public Health and Environment, but it’s a fantastic resource no matter where you live. Immunize Colorado keeps its fans in the loop on a broad range of immunization topics. Like the page to stay up-to-date on immunization legislation and advocacy, learn about your own vaccine status, and find other immunization organizations doing important work globally.

Sabin Vaccine Institute: “We’re advocates for a world free of needless suffering” reads Sabin’s About section, and it sums this organization up pretty well. These scientists know how important vaccines are to improving public health, and they want to educate the public. The group is globally focused, so expect updates on immunization news from around the world.

Gavi, The Vaccine Alliance: Gavi focuses on the many people in developing countries who don’t have access to vaccines at all. The aim: to increase access to immunization in underdeveloped communities around the world.  Their Facebook page gives detailed information about their important work. We especially love their photos and videos, highlighting the people who directly benefit from vaccine access in developing countries.

Looking for more? Check to see if your area’s immunization coalition has a Facebook account for immunization-related news and events in your local community.

5 Vaccines All Young Men Need (Because It’s Men’s Health Month)

mens-health-monthYoung men are half as likely to seek out preventive care services as young women. And because they’re skipping doctors visits, many young men aren’t getting essential details about their vaccination status. It’s important to receive boosters and new vaccinations throughout your life to prevent a wide range of diseases. For Men’s Health Month, here are five you should talk to your medical provider about getting.

Flu: The CDC recommends all adults get a flu vaccine every year of their life. Even so, the vaccination rate for men in the U.S. ages 18 to 64 was only 32.9 percent in 2013, compared to 40.4% for women of the same age, and 58.6% for children aged 6 months to 17. If you’re young and healthy, influenza can still cause fever, fatigue, headaches, sore throat and body aches. Most importantly: You also might pass it on to someone in a high-risk category, like children, pregnant women and the elderly, where it can prove fatal.

HPV: It’s not just for women. Human papillomavirus (HPV) can cause cancer of the anus, throat, and penis in men, yet only 5.9 percent of men ages 19-26 receive at least one dose of the 3-dose series. The Food and Drug Administration has approved the vaccine up to age 26, but it’s best to get vaccinated at age 11-12 before you’re sexually active. Even if you are already sexually active, the shot can still protect you against strains of HPV you haven’t been exposed to.

Tdap: The shot protects against three diseases: tetanus, diphtheria, and pertussis. Even if you received a similar vaccine as a kid, you still need a booster shot as an adult. Tetanus can cause muscle stiffening, and diphtheria can affect breathing. Pertussis (known as whooping cough) is extremely contagious, and can cause violent coughing episodes, often lasting for weeks. A lot of adults with whooping cough don’t even realize they’re sick and can unknowingly spread the disease to small kids. All men should get the Tdap vaccine, along with a booster dose every 10 years of the Td (tetanus and diphtheria) vaccine.

MMR: This shot protects against measles, mumps, and rubella, three diseases with varying degrees of fever, coughing, and rashes. Measles was almost wiped out in the U.S., but falling vaccination rates in some communities have made it more common in recent years (remember that Disneyland outbreak?). If you missed the MMR vaccine as a kid, it’s not too late. Talk to a healthcare professional about how many doses you need as an adult.

Hep A and B: Both of these liver infections can cause long-term problems, including cancer and cirrhosis of the liver. If you’re planning to travel to South or Central America, Africa, the Middle East, or India, you should get the Hep A vaccine, since the disease is more common in those areas. Get Hep B if you’ve lived with an infected person, have sex with multiple partners, or have sex with other men, since these behaviors put you at greater risk for the disease.

Your Weekly Dose 6.19: All the Vaccine News You Missed

Measles hits a 16-year high in Australia, a tragic death inspires a lasting legacy, and mountaineers are the unsung vaccine heroes of Nicaragua.

One Infant’s Legacy: Australian newborn Riley Hughes died at 32 days from complications due to pertussis, but his parents have used the heartbreaking story to launch a free vaccination program for pregnant women — more than 3,000 women have received the vaccine since the program began in March. []

Measles Spikes in Australia: At least 340 cases of measles were recorded in Australia this year, marking a 16-year-high in the country. Compare that to 2008, when only 10 people came down with the vaccine-preventable disease. [mamamia]

Get Vaccinated, Chicago: At least three cases of meningitis have been recorded in Chicago, which means one thing—get vaccinated. Particularly at-risk groups include men who have sex with men, and men with HIV. [Washington Blade]

Nicaragua’s Unsung Vaccine HeroesMountaineers are true heroes in Nicaragua, where temperature-sensitive vaccines are delivered to remote villages by horseback (or whatever means necessary). [devex]

The Essential Vaccine Pregnant Women Aren’t GettingA staggering 86 percent of pregnant women aren’t getting their Tdap vaccines, a dose that prevents tetanus, diphtheria, and pertussis, and is essential to get when a woman is between 27 and 36 weeks pregnant. []

5 Reliable (and Interesting!) Vaccine News Twitter Accounts to Follow Now

Twitter can be a great resource for accurate vaccine information. But with so many people talking about the issue, it’s hard to cut through the noise and know which accounts are reliable. A good place to start (besides us)? These five twitter accounts, which we love for their important insights, lively debates, and (crucially) trustworthy information. Follow them now!

@NFIDVaccines: This is a great one-stop shop for both vaccine news and practical information on keeping your vaccination status up to date. The best part: NFID posts plenty of retweet-worthy info graphics, perfect for keeping your own account fresh.

@Voices4Vaccines: Voices for Vaccines is a group of parents who provide clear, science-based information on immunizations to other parents to combat misinformation. Follow for reliable information about vaccine safety and effectiveness, as well as personal accounts of why vaccination matters.  

@shotofprev: This is the Twitter account for Shot of Prevention, a blog that provides perspectives, personal stories and analysis on vaccination-related news and topics. Watch them for updates on what’s going on in the immunization community and info into timely legislation, such as SB277, the California bill that would require all public and private school students to be vaccinated.

@gavi: Gavi’s Twitter account provides a more global perspective on immunizations and focuses on the many people in developing countries who don’t have access to vaccines at all. The aim: To increase access to immunizations in communities around the world. Follow for news on their work, plus updates on vaccine access in developing nations.

@sabinvaccine: The Sabin Vaccine Institute is working to combat vaccine-preventable and neglected tropical diseases around the globe by promoting existing vaccines and developing new ones. Follow this account for the latest news and research on vaccines and vaccine development.

Looking for more? Check to see if your area’s immunization coalition has a Twitter account for immunization-related news and events in your local community.

Your Weekly Dose: All the Vaccine News You Missed

Astronaut fixing space ship.

This guy needs his flu shot, too. CC0 Public Domain / FAQ

California legislators vote in favor of a major vaccine bill, the HPV vaccine becomes even more of a no-brainer, and astronauts need the flu shot, too.

California Passes Vaccine Bill: Following five hours of debate, legislators in California’s Assembly Health Committee voted 12-6 in favor of a bill that will get rid of the state’s personal-belief exemption and require unvaccinated children to be homeschooled. Bill SB277 is a response to an early 2015 outbreak at Disneyland. Thanks, Mickey? [KSBY]

Astronauts Not Invincible, Need Flu Shots, Too: Think everything’s spic and span and sterile aboard the International Space Station? Not so much: “Bacteria and viruses adore the environment of a spacecraft: it’s warm, it’s sealed, it’s climate-controlled, and best of all it’s full of people who have nowhere to go and no way to avoid sharing any stray germs they might have brought with them.” Yep, that includes the flu. [Time]

All You Need Is One: Perhaps the best news of the week? A major new study found that just one dose of the 2vHPV vaccine (commonly known as Cervarix) could be enough to protect against two strains of the virus associated with several types of cancer, including cervical cancer. This is encouraging, but don’t go skipping your doses —more research is required before any conclusions can be made. [Huffington Post]

Measles Come to Alaska: The first case of measles in more than a decade was confirmed in Fairbanks, Alaska, this week. [Outbreak News Today]

Diptheria Arrives in Spain: Another bummer, from Spain: A six-year-old boy came down with the country’s first case of diphtheria in nearly 30 years. Eight children who came in contact with him are being kept in isolation. [Daily Beast]

HPV Vaccine Even More Effective: On the bright side, the newest version of 9vHPV offers as much as 11.1% more protection against cervical cancer than its predecessors. Hooray for preventing cancer! [Chicago Tribune]

AMA Backs End to Non-Medical Exemptions: The AMA sided with California legislators and backed an end to all non-medical exemptions. Though the AMA can’t make the laws, they can lobby for them. [Newsweek}

Why I care about neglected tropical diseases in Texas – and so should you.

CDC Global

CDC Global

By Jennifer R. Herricks, Ph.D.

Did you know that a group of infections known as neglected tropical diseases, or NTDs, afflict the people of Texas, even in big cities like Houston? Neither did I, until I began my postdoctoral work studying disease and poverty. I learned that these diseases affect people’s ability to work, learn and be productive, and that this burden falls disproportionately on the poorest Texans who have the least resources to deal with the repercussions.

This motivates me to do what I can to help our neighbors that suffer from these significant, yet understudied, conditions. One way we can all help is by talking with policymakers because they have the ability to make potentially lasting change. This April I had the perfect opportunity to share what I know about NTDs with Texas lawmakers. I describe that experience below, and I hope it inspires others to get involved with the political process when important issues are at stake.

During Texas’ current legislative session, Rep. Sarah Davis introduced House Bill 2055 regarding the establishment of a sentinel surveillance program for emerging and neglected tropical disease.  On April 21 the Texas House Committee on Public Health contemplated the bill, and I was there with Anna Dragsbaek, president and CEO of The Immunization Partnership, to provide testimony. Dr. Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine, provided written testimony.

Like most people, when the committee heard the term “neglected tropical diseases,” they thought about rare diseases that exist only in exotic locations. However, these diseases are not rare — affecting 1.4 billion people globally — and despite the word “tropical,” they can occur anywhere — especially in areas of extreme poverty — including the United States. And while diseases like chikungunya, dengue fever, Chagas disease and cysticercosis may sound exotic, they are very close to home. The combination of a mild climate, the presence of insect vectors and animal reservoirs, and high rates of poverty make Texas and the surrounding states a “hot zone” for NTDs.

In 2011 the National School of Tropical Medicine at Baylor College of Medicine established a Tropical Medicine Clinic at Ben Taub Hospital in the Texas Medical Center. Each week physicians at this Houston clinic see patients with one or more NTDs.

The question naturally arises, as it did in the public health hearing: How many Texans suffer from NTDs? The most recent estimate is that 12 million Americans live with at least one NTD. But, as we testified, a precise burden of NTDs in the U.S., and in the state of Texas it is difficult to attain for several reasons. Perhaps the most important is a lack of awareness about NTDs, even among the medical community. Due to this lack of awareness, many patients are undiagnosed or misdiagnosed and cases often go unreported.

Many of these diseases are chronic and debilitating. Neurocysticercosis can cause epilepsy; toxoplasmosis and toxocariasis can cause blindness and developmental defects in children; Chagas disease can cause fatal cardiomyopathy; trichomoniasis is associated with infertility and poor birth outcomes. Recent work has also linked NTDs to other conditions, such as asthma, mental illness and an increased susceptibility to HIV infection.

In addition, there are financial costs associated with NTDs. The economic burden of Chagas disease in the U.S. is projected to be almost $1 billion, and neurocysticercosis is estimated to cost $17 million in the state of California alone.

The good news is that these terrible consequences can be avoided if the right public health interventions are put in place. To do this efficiently and effectively, we need to have more accurate data about the true burden of these diseases in our communities. HB 2055 would enable the state of Texas to determine better disease estimates to meet this goal. Implementation would be simple, as this program can be rolled into existing disease surveillance mechanisms without additional costs.

These arguments were laid out before the Texas House Public Health Committee without opposition, and the bill recently passed the House, but there is still a long way to go. It must pass in the Senate before it can be sent to the governor. All of this must happen before the end of the Texas legislative session on June 1, or we have to start our efforts again during the next session in 2017. Knowing that the legislature is very busy, it is important to keep them engaged on this issue so that it is not simply put to the side.

Hearing from constituents can motivate elected officials to take action. For my part I am doing everything I can to let the Texas legislature know that HB 2055 is important to me and why it should be important to them and to all Texans. While it may not always be possible for me to go to Austin to tell them in person, I know I can reach them by phone, mail, e-mail, even twitter! I hope other Texans will also see the imperative need for HB 2055 and take action by talking to their elected officials. Together we can create the political will to tackle NTDs and other important issues in our towns, our state and our country.

Jennifer R. Herricks, Ph.D., is a postdoctoral fellow in disease and poverty at the National School of Tropical Medicine at Baylor College of Medicine and Rice University’s Baker Institute for Public Policy.

MMR, the CDC and Brian Hooker: A Guide for Parents and the Media

This post originally appeared on Harpocrates Speaks on September 8, 2014 and has been reposted here with permission from the author.  

MMR, the CDC and Brian Hooker: A Guide for Parents and the Media

The anti-vaccine community has been in a tizzy lately over a supposed “CDC whistleblower”, Dr. William W. Thompson, who, according to them, revealed fraud at the United States Centers for Disease Control and Prevention (CDC). To bolster their claim, they point to a new study from one of their own, Brian S. Hooker, that purports to show evidence of an increased risk of autism among African American boys who receive their first MMR vaccine late. However, the claims appear to be hollow and unfounded, and so they have chosen to rely on emotional arguments that may sound convincing to those who are not familiar with the issues and people involved. In a truly egregious fashion, they have erroneously and cynically compared this whole thing to the Tuskegee syphilis study, and equated the CDC with Adolf Hitler, Josef Stalin and Pol Pot, combined.

With that in mind, here is a brief FAQ for parents, news media and others to help them understand what the claims are and what the evidence actually says. The questions below have been raised or implied by anti-vaccine activists. Hopefully, this will prevent inaccurate reporting and help parents feel reassured about the MMR vaccine.

Did the CDC commit fraud?

A small group of vocal activists claim that the CDC committed fraud by intentionally covering up data. This group, which blames vaccines for a wide range of problems, offers no evidence in support of this claim. The closest they come is pointing to a statement released by a CDC researcher, William W. Thompson, in which he mentions a scientific disagreement over what data to publish in a 2004 paper on which he was an author (“Age at first measles-mumps-rubella vaccination in children with autism and school-matched control subjects: a population-based study in metropolitan Atlanta“). The study examined the age of first MMR vaccination and autism but found no association. While one could read into Thompson’s statement an implication of wrongdoing, he does not allege any fraud either on his part nor on the part of the rest of the team associated with the 2004 paper. Even though his statement makes no mention of fraud, some people who wish to scare people about vaccines and make others distrust the CDC point to his statement as evidence of fraud.

Did the CDC hide data from the public?

No. The data set used by the CDC in the 2004 paper has always been available to qualified researchers.Instructions on how to access these data are available on the CDC web site.

Did the CDC cover up a finding that the MMR vaccine is linked to autism?

From the facts that are known at this time, the CDC does not appear to have covered up anything. In 2004, the CDC conducted a study examined children with autism (cases) and those who don’t have autism (controls), then looked at the age of MMR vaccination to see if cases were more likely to have been immunized at a certain age than controls. While no clear association was discovered, they did notice that there was an odd finding that more cases than controls were vaccinated later than 24 months of age but before 36 months of age. To see if this apparent association was real, they gathered more information from state birth certificate records for all study subjects that had a Georgia birth certificate. This additional information allowed them to see if there might have been some other factor (e.g., birth weight, parents’ age, mother’s education level, etc.) that might have been responsible for the strange finding. Once the researchers controlled for these additional factors, the anomaly disappeared, meaning that there was no connection between MMR vaccination and autism. The published paper included the results of the birth certificate analysis by race and age at first MMR vaccination, but did not include a racial comparison from the larger group for age at first vaccination, because racial information was not available for all subjects, and that strange finding from the larger group was not reliable. Furthermore, as the subgroup analysis showed, that initial finding was wrong. In response to the noise from the anti-vaccine movement, the CDC released a statement in support of their original study.

Did CDC lie when they said they got more information from birth certificate records?

No. Many anti-vaccine activists, including Brian Hooker, have stated that the birth certificates do not contain the information the CDC researchers stated they obtained from them (birth weight, mother’s education, etc.). While the birth certificates that parents receive have limited information, a more complete worksheet (PDF) is completed by the hospital staff and kept on file with the state. The information on the Georgia state birth worksheet is similar to the U.S. Standard Certificate of Live Birth (PDF). These complete birth records have information on birth weight, whether the birth was premature or at term, if the baby was a twin/triplet/etc., the mother’s education level, and so on. [Edited to add (9/16/14): Parents’ education, for example, has been on the standard birth certificate since 1969 and still on it for the 1989 revised version.] The CDC researchers used these complete birth certificate records in their 2004 study. More information on the standard birth worksheet, including revisions, can be found on the CDC’sNational Vital Statistics System web site.

Did CDC use the birth certificate requirement to exclude African Americans from the study?

No. An early claim among anti-vaccine activists was that the CDC researchers only required birth certificates for African American children in their study so they could exclude them from the birth certificate subgroup analysis. This, so the claim goes, was so they could hide an association between MMR vaccine and autism among African American boys. But the researchers used birth certificates for all of the children in their study. This is illustrated in Table 2 from the 2004 study (reproduced here for commentary):

Click to enlarge.
From: DeStefano, et al. (2004). “Age at First Measles-Mumps-Rubella
Vaccination in Children With Autism and School-Matched
Control Subjects: A Population-Based Study in Metropolitan Atlanta”

The birth certificate requirement was not used to suppress data on African Americans. This anti-vaccine claim appears to have been made specifically to exploit race and stir up fear and anger in the African American population.

Was the decision to use birth certificates arbitrary and irrelevant?

No. As the authors of the 2004 study note (emphasis added):

Among case and control children whose records we were able to match with Georgia birth certificate files, we performed a subanalysis to evaluate possible confounding by differences in birth and maternal characteristics.

The full study population data showed a possible association between age of first MMR and autism, but the data did not contain information that may have pointed to other causes of that association. The birth records did have that information, and allowed the researchers to discover that the MMR was notassociated with autism.

Did a new study find that there is an increased risk of autism in African American boys?

A study (“Measles-mumps-rubella vaccination timing and autism among young african american boys: a reanalysis of CDC data“) published in August 2014 in the journal Translational Neurodegeneration by Brian S. Hooker did conclude that there was an increased risk of autism in African American boys who were given their first MMR vaccine between 24 and 31 months of age (Hooker cut off at 31 months, rather than 36 months as in the CDC study, because, after excluding low birth weight infants, there were “insufficient cases” at 36 months; the subgroup he analyzed is different than in the CDC’s study). His study also found that there was no association between MMR and autism at other ages, nor was there any association for African American girls nor for children of any other racial category. However, his results regarding African American boys are almost certainly wrong.

The original 2004 study by the CDC was what is called a case-control study. (A case-control study takes two matched groups, one with a condition and one without, and looks to see how likely or frequently they were exposed to a potential risk factor. It can suggest associations, but usually doesn’t prove causation.) The data for that study were collected with the case-control design in mind. Hooker’s study appears to be a cohort study, which is a completely different type of study design, yet he used the same CDC data set that was designed for a case-control study. (A cohort study starts with people who do not have the disease of interest, then follows them to see if different levels of exposure to a suspected risk factor increases the risk of the disease or condition of interest.) Using data designed for use in one type of study design in a study with a completely different design can introduce errors into the analysis. Hooker then used an inappropriate statistical analysis (either Pearson’s chi-squared test, as mentioned in the Methods, orFisher’s exact test, as noted in the tables) to analyze the data. This type of test ignores variables that can skew results, as well as making a small signal seem very large. Hooker admitted in a presentation at an anti-vaccine conference (around the 17:00 mark) on August 29, 2014 that he used a very simple technique, that “simplicity is elegance”, and that he prefers to do simple things rather than intellectually challenging things. However, elegant does not mean correct; his “simple” analysis ignored confounding variables. Another shortcoming of the study is that Hooker does not report the number of individuals included in his subgroup analyses. The size of the groups matters. The smaller the group, the more likely a finding is due to chance. Since publication, the journal has withdrawn Hooker’s study due to concerns about the validity of its conclusions as well as possible conflicts of interest that were not disclosed by Hooker or the peer reviewers who reviewed the study. [UPDATE (10/4/14): The journal has fully retracted Brian Hooker’s paper due to undeclared conflicts of interest and invalid statistics and methods.]

Who is Brian Hooker?
Brian S. Hooker is the father of an autistic child. He has a degree in biochemistry, but has no formal training in statistics or epidemiology, nor is he trained in any field pertinent to the study of vaccines or autism (e.g., immunology, vaccinology, childhood development, developmental psychology, etc.). Hooker has an open case claiming vaccine injury for his son before the Vaccine Court. He is also a board memberof an anti-vaccine organization called Focus Autism. Focus Autism is the organization that funded Hooker’s study. Hooker is also ideologically opposed to vaccines and the CDC, as evidenced by an email he sent to former director of the CDC, Julie Gerberding, in which he wrote, “I would personally urge you to review the Book of Matthew 18:6 and consider your own responsibility to all children of the U.S. including my own son.” The referenced Bible passage reads (King James Version):

But whoso shall offend one of these little ones which believe in me, it were better for him that a millstone were hanged about his neck, and that he were drowned in the depth of the sea.

What do you mean by undisclosed “conflicts of interest”?

Authors of scientific articles are supposed to provide a clear statement of any conflicts of interest that might bias their results. The purpose is to make the reader aware of what might influence the author’s conclusions regarding the data and findings they are reporting. In his study, Brian Hooker only disclosed that he “has been involved in vaccine/biologic litigation”. The statement implies that he is not currently involved in litigation related to vaccines. In reality, Hooker has an active case before the Vaccine Court in which he is suing the government for what he claims is his son’s vaccine-induced autism. He stands to benefit from studies that find a connection between vaccines and autism. He also fails to disclose that he is a board member of the anti-vaccine organization Focus Autism, which funded the study.

The journal in which Hooker published his study, Translational Neurodegeneration, allows authors to submit suggestions for possible reviewers. These reviewers ought to be experts in the relevant fields and should not have strong personal or business ties to the study authors. The journal may choose to use the reviewers suggested by the authors, or they might pick researchers who have published papers previously in the same journal on the same or related subject. We do not know who the reviewers were, but there are some likely candidates, none of whom are qualified to act as peer reviewers and have numerous conflicts of interest, including working relationships with Hooker.

Did Hooker’s study prove Andrew Wakefield right?

No, it did not. Andrew Wakefield has long advocated the belief that the MMR vaccine causes autism. If we ignore all of the flaws in Hooker’s 2014 study and assume that his findings are accurate, Hooker’s study shows that the MMR is not associated with autism. In other words, Hooker’s study, if it is accurate, proves Andrew Wakefield (and much of the anti-vaccine movement) wrong. The only group in which Hooker found an association (and even that association is not proof of causation) was among African American boys who got the MMR vaccine late (between 24 and 31 months). But, as noted above, Hooker’s study was quite flawed and so his findings are very likely incorrect.

Was Hooker’s study retracted?

Yes. On October 3, 2014, the journal Translational Neurodegeneration fully retracted Brian Hooker’s study, issuing this accompanying statement:

The Editor and Publisher regretfully retract the article [1] as there were undeclared competing interests on the part of the author which compromised the peer review process. Furthermore, post-publication peer review raised concerns about the validity of the methods and statistical analysis, therefore the Editors no longer have confidence in the soundness of the findings. We apologise to all affected parties for the inconvenience caused.

PubMed has also updated their listing for the study, with large red box warnings that the study has been retracted and “RETRACTED” stamped in block print across the face of the study text:

Click to enlarge.

The Bottom Line

Despite much noise being made by the small, yet incredibly vocal, anti-vaccine community, there is no evidence of fraud on the part of the CDC, nor is there convincing evidence of any cover-up. Brian S. Hooker’s study contains a number of flaws leading to a spurious, and biologically implausible, conclusion. In fact, the quality of the study is such that the journal that published it withdrew it pending further investigation, citing serious concerns about the validity and potential conflicts of interest. This entire issue is, in reality, much ado about nothing. It is just another example of anti-vaccine activists doing bad science to put your children at greater risk of harm, all because they cannot accept their own children as they are.
Further Reading:

Posts discussing Hooker’s allegations, excluding anti-vaccine sources


Posts discussing Hooker’s allegations from anti-vaccine sources


Other links

2 bills that could save lives

This post originally appeared in TribTalk, a publication of The Texas Tribune, on May 1, 2015. 


By , and

As families who have dealt with meningitis, we understand all too well the pain wrought by this terrible disease.

Greg is the parent of a college student who died from meningitis. Patsy is the mother of Jamie, a student who survived the disease but lost both legs and several fingers.

All Texas families can learn the critical and fundamental importance of vaccinations from our experiences, and we take seriously our responsibility to promote vaccines.

Meningitis is a fast-killing disease that can be fatal to an average healthy individual within 24 hours. While the disease is rare, surviving it is even rarer, and many survivors are permanently scarred or disfigured. Jamie not only survived meningitis but also recently graduated from the University of Texas at Austin, and she is traveling the world to encourage other young people to protect themselves against preventable diseases.

The Texas Legislature is again debating immunization policies, and a small but loud group of anti-immunization activists has again appeared at the Capitol. While all Texans are entitled to their own opinion, protecting the health and safety of all children should take precedence over any personal agendas. For families affected by these terrible and preventable diseases, vaccines aren’t a fad — they’re the foundation of basic, cost-effective health care.

All Texans should have the ability to protect their children from disease and to help those children become protected adults. That’s why we ask the Texas Legislature to listen to science and prioritize Senate Bill 298 by state Sen. Kirk Watson, D-Austin, and House Bill 2171 by state Rep. J.D. Sheffield, R-Gatesville. This legislation would make it easier for us to protect our children by easing college admission and making sure that all children have access to their shot records as they transition to adulthood.

Meningitis doesn’t wait for college. A student at Kingwood High School near Houston recently died from the disease. Watson’s bill would implement guidelines from the Centers for Disease Control and Prevention to add a meningitis booster in high school, helping to prevent more needless deaths among young students.

The bill would also ensure that students have the meningitis shot required for college admission. Texas was the first state in the country to require meningitis vaccination for college students and is already seeing a surge in immunization rates thanks to highly successful meningitis laws. And under Watson’s bill, because the cost of the immunization can be high, the federal government’s Vaccines for Children program — not students or the state — would pick up the tab.

Sheffield’s bill would help young adults maintain access to their immunization records. Currently, the state’s immunization registry only gives young adults one year to ask the state to not delete their shot history. With Sheffield’s bill, Texans would have until their 26th birthday to opt to keep their immunization records on file for later use for employment and college admission. In an ideal world, 18-year-olds would care about their shot records. Sheffield’s bill would simply give young adults more time to opt in to the registry as adults.

As the 2015 Texas legislative session begins to wind down, it’s critical that lawmakers prioritize these bills. It is not an exaggeration to say that they would save lives. Hundreds of thousands of Texans would immediately get the protection we know they need.

Our families were touched by a preventable disease. Help us make sure fewer families share our experience.